Verification of drug use involving delta-9-tetrahydrocannabinol (marijuana)
Delta-9-tetrahydrocannabinol (THC) could be the active representative for the popularly street that is abused, cannabis.
After usage of the drug, either by breathing or ingestion, it really is metabolized to many different inactive chemical substances, one of these being delta-9-tetrahydrocannabinol acid that is carboxylic.
In just about all medico-legal instances plus in testing of workers, or once the client adamantly denies THC usage and also the test that is immunoassay good, verification for the outcome by fuel chromatography-mass spectrometry (GC-MS) is needed.
The existence of tetrahydrocannabinol carboxylic acid (THC-COOH), a significant metabolite of delta-9-tetrahydrocannabinol, in urine at levels higher than 15.0 ng/mL is an indicator that is strong the in-patient has utilized cannabis.
The metabolite of cannabis (THC-COOH) has a lengthy half-life and may be detected in urine for longer than seven days after a solitary usage. The clear presence of THC-COOH in urine more than 100.0 ng/mL shows use that is relatively recent most likely in the past 1 week. Levels more than 500.0 ng/mL recommend chronic and current usage. Chronic usage causes accumulation of THC and THC-COOH in adipose muscle so that it is excreted in to the urine so long as 30 to 60 times through the time chronic usage is halted.